Frontline Plus Flea and Tick Treatment for Large Dogs 45-88 lbs, 6 Doses

Heavy-Duty Protection for Your Large Dog

Big dogs live big lives — and they need protection that can keep up. Frontline Plus Flea and Tick Treatment is specially formulated for large dogs weighing 45 to 88 lbs, delivering a full 6-month supply of vet-recommended flea and tick defense. From sprawling hikes to lazy afternoons in the yard, Frontline Plus ensures your large dog stays comfortable, itch-free, and protected against the pests that can cause serious health issues if left unchecked.

Proven Dual-Action Formula That Stops Infestations at the Source

Frontline Plus doesn't just treat the surface — it eliminates the entire flea life cycle. Its powerful combination of fipronil and (S)-methoprene kills adult fleas within 12 hours and ticks within 48 hours, while simultaneously destroying flea eggs and larvae before they can develop into a full infestation. The waterproof formula holds strong through baths, rain, and outdoor adventures, so your large dog stays protected month after month without interruption.

Six Months of Coverage, One Simple Application

Each box contains 6 pre-measured doses — one per month for a full 6-month supply. Application takes just seconds: part the fur between your dog's shoulder blades and apply directly to the skin. No mess, no stress. Trusted by veterinarians and pet owners across the US, Frontline Plus ships fast so your large dog gets the powerful, long-lasting protection they deserve without delay.